Her husband, playwright David Rabe, told the Associated Press that she had suffered for 21 years from chronic lymphocytic leukemia.
Adept at creating women of both intelligence and emotion, she was regarded as one of the first film figures to bring depth and subtlety to characters who reflected the sensibilities of their times, the 1970s in particular.
A career highlight was her role as a divorced woman who begins to search out her options and opportunities in That 1978 movie drew one of her two Academy Award nominations.
The other Oscar nomination came for (1979), in which she was the emotional victim of the psychic uncertainties of the character played by Burt Reynolds.
Other well known films included in which she was remembered for projecting both intellectual brilliance and an agitated emptiness.
Clayburgh was also in as the daughter of a pro football team owner and in She was plausible as a Supreme Court justice in
At least one moviegoer described her work as melding strong feeling with everyday gestures, permitting a tentative, shaky smile to cross her face just before she exploded with emotion.
Over four decades of performing, in both comedy and dramatic roles, she also made many television appearances, meeting the demands of soap opera skillfully, and winning Emmy nominations for parts that demanded greater range , including and.
On Broadway, she played in Noel Coward's and in two musicals that won the theater's Tony Award, and
Clayburgh was born April 30, 1944, the daughter of well-off New Yorkers, and attended a private school in Manhattan as a child, before going to to Sarah Lawrence College.
Her father was a business executive; her mother was a secretary for celebrated Broadway executive David Merrick. A grandmother had been an opera singer.
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